Should MHS Patients Be Pretreated With Dantrolene?

Dantrolene prophylaxis is not recommended for most MH-susceptible patients. Dantrolene can worsen muscle weakness in patients with muscle disease and should be used with caution. Therefore, dantrolene prophylaxis may be omitted, provided non-triggering anesthetics are used, there is appropriate monitoring, and an adequate supply of dantrolene is available.