How Much Dantrolene Should Be Kept On Hand?

To treat an MH episode, an initial dose of dantrolene at 2.5 mg/kg is recommended, with a suggested upper limit of 10 mg/kg. If a patient of average weight (approximately 70 kg) were to require dantrolene at the upper dosing limit, then at least 700 mg of dantrolene would be needed.

• DANTRIUM^®/REVONTO^® – stock a minimum of 36 - 20 mg vials
• RYANODEX^®– stock a minimum of 3 - 250 mg vials

In addition, a review of cases has shown that in a “worse case” scenario of a very large person (i.e., about 100-110 kg or 220 – 250 pounds) having an acute MH incident, as much as 8-10 mg/kg will be needed for treatment; higher doses may be required on rare occasions.

This regimen of dantrolene will allow for initial stabilization and treatment while more vials are being acquired to continue treatment, as needed.

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